Liquisolid systems: Evaluation of the influence of formulation variables on the optimum liquid load

Liquisolid systems represent an emerging approach in the preparation of solid dosage forms with liquid lipophilic drug or poorly water-soluble solution/suspension suitable vehicle. This study addresses lack data regarding compaction behavior liquisolid systems, aim to investigate influence load, carrier coating ratio, type (microcrystalline cellulose vs. spray dried calcium hydrogen phosphate, anhydrous (Fujicalin®)) on flowability and properties determine optimum loads. admixtures Fujicalin® showed notably better than those microcrystalline cellulose. An increase ratio led enhanced admixtures. Compacts had good mechanical up 24.7% liquid, while acceptable strength 16.2% liquid. similar tabletability profiles as cellulose, despite having higher content. The ejection stress values indicated that addition lubricant might be needed case Fujicalin®. Superior a for tablets were revealed, dynamic analysis was found valuable tool assessment systems.